A study of the cell-mediated immunity in patients with pulmonary tuberculosis

دراسة المناعة الخلوية لدى مرضى التدرن الرئوي

الملخص

Abstract:

Objectives:

Assessment of certain cell mediated parameters during different clinical stages of pulmonary tuberculosis (PTB).

Materials and method:

Two hundred and ten patients with different clinical stages of PTB and 105 healthy individuals were enrolled in this study. Both study groups were submitted to; tuberculin skin test (TST) to assess the delayed type hypersensitivity resection (DTH); skin sensitization to 1-chloro 2,4-dinitrobenzene (DNCB) to determine the non-specific immune response (NIR); assessment of peripheral phagocytic activity (PPA) by nitro-blue tetrazolium (NBT) reduction test. Additionally, correlation of these immune parameters with peripheral total CD₄⁺ and CD₈⁺ T lymphocyte counts were also sought.