Synthesis of Barbiturate Derivatives from Imines

توليف مشتقات الباربيتورات من Imines

Abstract

Barbiturates were prepared involving the reaction of aromatic Schiff bases with benzoyl chloride to give N-[α-chloro-α-dimethylaminobezyl]-N-aryl-benzanilide. The reaction of the latter with diethylmalonate in basic media to give N-[α-diethylmalonyl-α-p-dimethylaminobenzyl]-N-aryl-benzanilide. The latter condense with urea in basic media afforded derivatives of barbiturate which known to act  as hypnotics.