The Effect of Some Polyphenolic compounds on Serum Peroxynitrite of Leukemics تأثير بعض مركبات البوليفينول على بيروكسينيتريت مصل اللوكيميا

الملخص

The production of reactive oxygen species in most diseases including leukemia (type of cancer) is confirmed to be the most destructive process to human cell.

          Potent antioxidant is needed to overcome the lipid peroxidation and oxidative stress. Polyphenolic compounds are group of naturally occurring compounds in different plants. They are promising product to protect, and prevent leukemia and many types of cancer by different mechanisms.

          The effect of polyphenolic compounds (ellagic and tannic acid) on peroxynitrite was investigated on ninety patients with different types of leukemia (AML, ALL, CML and CLL), and seventy five healthy individuals as control group. The age of all studied groups range from (18-40) years. The results revealed the effectiveness of ellagic acid (EA) and tannic acid (TA) in lowering peroxynitrite levels in sera of  leukemic patients  in vitro study, which  the peroxynitrite concentration was reduced to normal value. The results showed that EA was most potent than TA.