Insulin effect on inflammatory response compared to sulfonylurea in diabetes mellitus patients

Abstract

This study was designed to state the ground stone of the role of the insulin as anti-inflammatory agent in different inflammation process.

        Fasting venous blood samples were taken from 150 subjects of which 50 patients with type 1 diabetes, 50 patients with type 2 diabetes, and 50 healthy individuals.

        All the blood samples were analyzed for F.B.S, HbA₁c %, TP, albumin, ESR, CRP,and immunoglobulin  alpha₁-antitrypsine.

         The present study results detected an increase in F.B.S, and HbA₁c % in sera of all patients of type 1 and type 2 compared for control.

Total protein levels showed no alteration in sera of both patients groups compared for control.

Decrease in albumin level was detected in sera of patient with type 2 group compared for patients with type 1 and control groups.

The factors for diagnosis of any type of inflammatory process ESR, CRP, alpa₁-antitrypsine were raised in patients with type 2 groups compared for patients with type 1 and control groups.